Studies Have Shown That Cannabidiol May Reverse Opioid Overdose
In the United States the opioid crisis is in an alarming state and a call to make drugs like naloxone, a fast-acting antidote for opioid overdose, is on high demand. Unfortunately, naloxone may not completely overcome drug overdoses as there are limitations in its effectiveness when dealing with synthetic opioids like fentanyl, researchers have been looking for an alternative treatment in CBD. Scientist now believe that CBD-based compounds have the potential to decrease fentanyl and enhance naloxone's effects.
Opioid is a fatal health epidemic in the U.S. at the moment and Fentanyl is responsible for 80% of opioid overdose deaths. With naloxone being the only available drug to reverse overdoses so it's only logical for there to be a need to find an alternative. The narcotics business is making a lot of money and there is no reason for them to stop the illegal trend anytime soon.
The researchers led by Alex Straiker, Ph.D. and Michael VanNieuwenhze, Ph.D. will present their case to the American Chemical Society (ACS).
Upon studying the possibility of cannabidiol as an alternative for opioid overdose reversal, the researchers explain that ideally they would have love to find a more potent replacement for naloxone, but as the same time finding something that could work along with naloxone to enhance the effects would lessen the need for naloxone and would be deemed a success too.
Opioids are prescribed to treat pain, but it is readily available illegally on the streets. The situation is getting out of hand and The U.S. Center for Disease Control and Prevention estimated that half a million people died from opioid overdose between 1999-2020 and the numbers are on the rise.
Naloxone reverse overdoses from opioids rapidly by binding to the same receptors in the brain as opioid does. It competes with the same receptors as opioid does as a result it blocks opioid from binding and reverse the effects, but for example fentanyl which is a synthetic class of opioid binds with the receptors very fast making naloxone to not be able to work effectively. Evidence shows that overdoses from opioids require multiple doses of naloxone to work.
Scientists have tried but are unable to find a stronger antidote yet. Scientists have been branching out looking for other blockers to replace or help enhance the effects of naloxone. A research in 2006 showed that CBD can interfere with opioid binding by altering shape of the receptors. When CBD is used with naloxone it accelerated the effects of the medication and as a result force the opioid to release the receptors. The researchers did experiment with different formations of CBD and dosaged and the results have been positive even with very low amounts. Bosquez Berger, a member of the team commented that “we hope our approach leads to the birth of new therapeutics, which, in the hands of emergency personnel, could save even more lives.”
On the other hand if you are looking for a natural holistic supplement to help your sleep better, relieve pain and inflammation, reduce stress and anxiety or to boost your general health and well being then CBD may be your answer.
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Written by Vivek Roachthavilit
Healthline
Analytical Cannaabis
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